Forskolin

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For R&D use only.

Catalog NO.：A850885
CAS No. : 66575-29-9
Molecular Formula：C₂₂H₃₄O₇
Molecular Weight： 410.50

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Quality Control&SDS

SDS COA HPLC/GC NMR

Product Details

CAS Number	66575-29-9	Appearance	White powder
Catalog Number	A850885	MDL Number	MFCD00082317
Molecular Formula	C₂₂H₃₄O₇	Molecular Weight	410.50
Boiling Point		Melting Point
Flash Point		Density
Synonyms	(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
Storage Condition	Store in a tightly closed container,in a cool and dry place

Safety

GHS Pictogram
Signal Word	Warning	UN Number
Hazard Statements	H312	Class
Precautionary Statements	P280	Packing Group

Description

LDN-212854 is a potent and selective BMP receptor inhibitor with IC50 of 1.3 nM for ALK2. LDN-212854 exhibits some selectivity for ALK2 in preference to other BMP type I receptors, ALK1 and ALK3, which may permit the interrogation of ALK2-mediated signaling, transcriptional activity, and function. LDN-212854 potently inhibits heterotopic ossification in an inducible transgenic mutant ALK2 mouse model of fibrodysplasia ossificans progressiva. The bone morphogenetic protein (BMP) signaling pathway has essential functions in development, homeostasis, and the normal and pathophysiologic remodeling of tissues. Small molecule inhibitors of the BMP receptor kinase family have been useful for probing physiologic functions of BMP signaling in vitro and in vivo and may have roles in the treatment of BMP-mediated diseases.

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H200	Explosives (Unstable Explosive)
H201	Explosives （Div 1.1)
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H330	Acute toxicity,inhalation (Category 1, 2)
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